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Preface .......................................................................................v
Contributors .............................................................................. ix
PART I: MOLECULES AND PATHWAYS OF APOPTOSIS
1 * Caspases: Structure, Activation Pathways, and Substrates ................................ 3
Brona M. Murphy and Seamus J. Martin
2 * Bcl-2 Family Proteins: Master Regulators of Apoptosis................................... 13
Xiao-Ming Yin, Wen-Xing Ding, and Yongge Zhao
3 * Inhibitors of Apoptosis Proteins ..................................................... 29
Peter Liston, Wai Gin Fong, and Robert G. Korneluk
4 * Structural Biology of Programmed Cell Death ............................................ 47
Yigong Shi
5 * The Death Receptor Family and the Extrinsic Pathway ........................ ........... 67
Maria Eugenia Guicciardi and Gregory J. Gores
6 * The Mitochondrial Apoptosis Pathway .................................................... 85
Bruno Antonsson
7 * From Caspases to Alternative Cell-Death Mechanisms .................................... 101
Marja Jiitteld and Marcel Leist
PART II: APOPTOSIS IN ACTION
8 * Apoptosis in Plants, Yeast, and Bacteria .............................................. 125
Ron Mittler and Vladimir Shulaev
9 * Programmed Cell Death in C. elegans ................................................... 135
Yi-Chun Wu and Ding Xue
10 * Cell Death in Drosophila ................................ ....................... 145
Sujin Bao and Ross L. Cagan
11 * Cell Death in Mammalian Development ................................................... 163
Chia-Yi Kuan and Keisuke Kuida
12 * Apoptosis and Cancer: Pathogenic and Therapeutic Implications ......................... 177
Sean L. O'Connor, Fermin Briones, Nikhil S. Chari, Song H. Cho,
Rebecca L. Hamm, Yoshihiko Kadowaki, Sangjun Lee, Kevin B. Spurgers,
and Timothy J. McDonnell
13 * Cell Death in Immune, Inflammatory, and Stress Responses .............................. 201
J. John Cohen, Maria D. Devore, Mile Cikara, and Elizabeth A. Dowling
14 * Cell-Death Mechanisms in Neurodegenerative Diseases: Diversity
Among Cerebral Ischemia, Parkinson's Disease, and Huntington's
Disease ............................................................................ 211
R. Anne Stetler and Jun Chen
15 * Apoptosis in Ischemic Disease ........................................................ 225
Zheng Dong and Manjeri A. Venkatachalam
PART III: APPROACHES TO THE STUDY OF APOPTOSIS
16 * Analysis of Apoptosis: Basic Principles and Procedures ................................ 239
Li Bai, Jinzhao Wang, Xiao-Ming Yin, and Zheng Dong
Index ..................................................................................... 253
Library of Congress Subject Headings for this publication: Apoptosis